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KMID : 0385620150230010009
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Korean Journal of Psychopathology
2015 Volume.23 No. 1 p.9 ~ p.19
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Association of the Quality of Life with Homocysteine Levels in Old Age Schizophrenics
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Park Sin-Hyung
Cheon Jin-Sook
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Abstract
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Objectives : The aim of this study was to identify variables including homocysteine levels associated with the quality of life in old age schizophrenics.
Methods : The data were obtained from admitted schizophrenics with age over 65 (N=128, male 57, female 71) by semistructured interviews and measurements of quality of life (K-SQLS), functional activities of daily living(K-ADL), cognitive function (MMSE-K), severity of psychosis (K-PANSS) and depression (K-GDS).
Results : 1) The old age schizophrenics with increased homocysteine levels had significantly more males (p<0.05), higher Hcy levels and higher scores in the K-ADL, K-PANSS and K-GDS, and lower total scores of the MMSE-K (p<0.001, respectively). 2) The total scores of the K-SQLS were significantly higher in old schizophrenics with increased homocysteine levels. That is, the quality of life was significantly lower in old schizophrenics with increased Hcy. 3) The K-SQLS in old age schizophrenics had positive correlation with Hcy, K-ADL and K-GDS. and had negative correlation with MMSE-K and K-PANSS with statistical significance. 4) Variables influencing on the K-SQLS were Hcy and K-GDS according to regression analysis.
Conclusions : Applying strategies to reduce homocysteine levels and depression could be expected to improve the quality of life in old age schizophrenics.
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KEYWORD
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Old age schizophrenics, Quality of life, Homocysteine, Depression
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